Tina Cascone
蒂娜·卡斯科内
MD, PhD
Associate Professor, Department of Thoracic/Head and Neck Medical Oncology胸部/头颈部肿瘤内科副教授
👥Biography 个人简介
Dr. Tina Cascone is a pioneer in neoadjuvant immunotherapy for resectable NSCLC, having led foundational studies on nivolumab and combination regimens before surgery. Her research defines pathologic response endpoints and informs the curative-intent immunotherapy landscape.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Neoadjuvant Immunotherapy for Resectable NSCLC
Conducted foundational studies establishing neoadjuvant nivolumab and nivolumab plus ipilimumab as active preoperative regimens, demonstrating major pathologic response rates and manageable safety profiles.
Pathologic Response as Surrogate Endpoint
Advocated for and validated major pathologic response (MPR) and pathologic complete response as surrogate endpoints in neoadjuvant NSCLC trials, accelerating drug development in the curative setting.
Tumor Microenvironment in Immunotherapy Response
Investigates how baseline and on-treatment TME features, including TILs, tertiary lymphoid structures, and immune suppression, predict neoadjuvant immunotherapy response and guide combination strategies.
Representative Works 代表性著作
Neoadjuvant Nivolumab or Nivolumab plus Ipilimumab in Operable Non-Small Cell Lung Cancer
Nature Medicine (2021)
Demonstrated that neoadjuvant dual checkpoint blockade yielded higher MPR rates than nivolumab alone, supporting combination approaches in resectable NSCLC.
Neoadjuvant Chemo-Immunotherapy for the Treatment of Stage IIIA Resectable Non-Small-Cell Lung Cancer
Clinical Cancer Research (2021)
Showed that adding nivolumab to neoadjuvant chemotherapy increased pathologic response and survival endpoints in locally advanced resectable NSCLC.
Increased Systemic and Antitumor Immunity Following Combination Immunotherapy
Cancer Discovery (2021)
Mechanistically characterized systemic and intratumoral immune changes induced by neoadjuvant nivolumab/ipilimumab, linking immune activation to pathologic response.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Lecia V. Sequist
Massachusetts General Hospital / Harvard Medical School
Mark G. Kris
Memorial Sloan Kettering Cancer Center
Geoffrey R. Oxnard
Foundation Medicine / Harvard Medical School
Alice T. Shaw
Novartis Institutes for BioMedical Research / Massachusetts General Hospital
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留下邮箱，当我们发布与 Tina Cascone（The University of Texas MD Anderson Cancer Center）相关的新研究或访谈时，我们会通知你。
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