Mark G. Kris
马克·克里斯
MD
William and Joy Ruane Chair in Thoracic Oncology胸部肿瘤学威廉与乔伊·鲁安讲席教授
👥Biography 个人简介
Dr. Mark Kris is a founding father of thoracic oncology who led early gefitinib and erlotinib trials and co-discovered the predictive role of EGFR mutations in NSCLC. His five decades at MSKCC have shaped lung cancer treatment globally.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Discovery of EGFR Mutation Predictive Value
Co-authored the landmark 2004 NEJM paper identifying activating EGFR mutations as predictors of response to gefitinib, founding the era of precision oncology in lung cancer.
Antiemesis Standardization
Pioneered evidence-based antiemetic guidelines that became the standard for managing chemotherapy-induced nausea and vomiting globally, greatly improving patient quality of life.
NSCLC Treatment Guidelines
Long-standing contributor to ASCO and NCCN lung cancer guidelines, translating clinical trial data into actionable practice recommendations worldwide.
Representative Works 代表性著作
Gefitinib-Sensitizing EGFR Mutations in Lung Cancer: First Reports
New England Journal of Medicine (2004)
Co-discovery of activating EGFR mutations predicting gefitinib response, a watershed moment in lung cancer and precision oncology.
Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs
JAMA (2011)
Demonstrated feasibility of broad molecular profiling in routine NSCLC care, establishing the Lung Cancer Mutation Consortium framework.
Adjuvant Chemotherapy, with or without Postoperative Radiotherapy, in Operable Non-Small-Cell Lung Cancer
Lancet (2010)
Large meta-analysis defining the survival benefit of adjuvant chemotherapy in resected NSCLC, informing standard post-surgical care.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Massachusetts General Hospital / Harvard Medical School
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Foundation Medicine / Harvard Medical School
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Stephen V. Liu
Georgetown University / Lombardi Comprehensive Cancer Center
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