Lecia V. Sequist
莱西娅·塞奎斯特
MD, MPH
Professor of Medicine; Director, Center for Innovation in Early Cancer Detection医学教授；早期癌症检测创新中心主任
👥Biography 个人简介
Dr. Lecia Sequist is a pioneer in EGFR-mutant NSCLC, known for characterizing resistance mechanisms to EGFR inhibitors and advancing osimertinib use. She leads early cancer detection research at MGH and has shaped global treatment guidelines for lung cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
EGFR Resistance Mechanisms
Defined serial biopsy approaches and molecular resistance pathways (T790M, MET amplification) arising after first- and second-generation EGFR inhibitor therapy, directly informing third-generation drug development.
Osimertinib Clinical Development
Key investigator in AURA trials establishing osimertinib as standard-of-care for T790M-positive and first-line EGFR-mutant NSCLC, transforming patient outcomes worldwide.
Early Cancer Detection
Leads MGH's Center for Innovation in Early Cancer Detection, translating liquid biopsy and ctDNA technologies into clinical screening strategies for lung and other cancers.
Representative Works 代表性著作
Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer (FLAURA)
New England Journal of Medicine (2018)
Co-investigator on landmark FLAURA trial demonstrating osimertinib superiority over first-generation EGFR inhibitors in first-line treatment.
Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
Science Translational Medicine (2011)
Seminal study characterizing diverse resistance mechanisms through serial biopsies, establishing the field of EGFR resistance biology.
Sequential Afatinib and Osimertinib in Patients with EGFR Mutation-Positive Non-Small-Cell Lung Cancer
Journal of Clinical Oncology (2019)
Defined the sequential EGFR inhibitor strategy, maximizing benefit from targeted agents in EGFR-mutant NSCLC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Mark G. Kris
Memorial Sloan Kettering Cancer Center
Geoffrey R. Oxnard
Foundation Medicine / Harvard Medical School
Alice T. Shaw
Novartis Institutes for BioMedical Research / Massachusetts General Hospital
Stephen V. Liu
Georgetown University / Lombardi Comprehensive Cancer Center
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