Geoffrey R. Oxnard
杰弗里·奥克斯纳德
MD
Chief Medical Officer, Foundation Medicine; Associate Professor of MedicineFoundation Medicine首席医疗官；副教授
👥Biography 个人简介
Dr. Geoffrey Oxnard is a global leader in liquid biopsy application for lung cancer, pioneering plasma ctDNA testing for EGFR resistance detection. His work bridges genomic technology and clinical decision-making for NSCLC patients worldwide.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Plasma ctDNA for EGFR Resistance Detection
Demonstrated that plasma genotyping could detect T790M and other resistance mutations non-invasively, enabling treatment selection without repeat tissue biopsy in EGFR-mutant NSCLC.
Cell-Free DNA Cancer Screening
Led clinical development of multi-cancer early detection through cfDNA, including key validation studies for Galleri test, advancing population-level cancer screening science.
Osimertinib Resistance Landscape
Characterized the diverse on-target and off-target mechanisms of acquired resistance to osimertinib through large-scale plasma sequencing, guiding next-generation combination strategies.
Representative Works 代表性著作
Plasma Genotyping for Therapeutic Targets in EGFR-Mutant Lung Cancer
Journal of Thoracic Oncology (2016)
Validated plasma EGFR testing as a clinically actionable tool for resistance monitoring, transforming the practice of NSCLC disease surveillance.
Detection of Cell-Free DNA Alterations for Multi-Cancer Early Detection
Annals of Oncology (2020)
Landmark validation study showing cfDNA methylation patterns can signal cancer presence across multiple tumor types with high specificity.
Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291
Nature Medicine (2015)
First comprehensive characterization of osimertinib resistance mechanisms, identifying C797S and bypass pathways that remain clinically relevant.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Stephen V. Liu
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