Stephen V. Liu
斯蒂芬·刘
MD
Associate Professor of Medicine; Director of Thoracic Oncology医学副教授；胸部肿瘤学主任
👥Biography 个人简介
Dr. Stephen Liu is a leading expert on KRAS-mutant NSCLC and was a key investigator in CodeBreaK 100 and KRYSTAL-1 trials establishing sotorasib and adagrasib. He also advances immunotherapy biomarker research and access to clinical trials.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
KRAS G12C Inhibitor Clinical Trials
Key investigator for CodeBreaK 100 (sotorasib) and KRYSTAL-1 (adagrasib) trials, contributing to the first approved KRAS inhibitors and validating KRAS G12C as a druggable target in NSCLC.
KRAS Combination Strategies
Leads research on overcoming KRAS inhibitor resistance through combinations with SHP2 inhibitors, MEK inhibitors, and immunotherapy, addressing the challenge of adaptive resistance.
Thoracic Oncology Education and Advocacy
Prolific educator and ASCO, IASLC contributor advancing molecular testing awareness, clinical trial access, and guideline adoption for KRAS and other rare NSCLC driver mutations.
Representative Works 代表性著作
Sotorasib for Lung Cancers with KRAS p.G12C Mutation (CodeBreaK 100)
New England Journal of Medicine (2021)
Pivotal phase II trial demonstrating durable responses with sotorasib, leading to FDA approval of the first KRAS-targeted therapy for NSCLC.
Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRAS G12C Mutation (KRYSTAL-1)
New England Journal of Medicine (2022)
Phase II data supporting FDA approval of adagrasib, confirming KRAS G12C as a tractable lung cancer target with a second distinct agent.
Molecular Profile and Outcomes of KRAS-Mutant Non-Small Cell Lung Cancer
Journal of Thoracic Oncology (2019)
Comprehensive analysis of KRAS co-mutation landscape and clinical outcomes, establishing the prognostic and predictive context for KRAS-targeted trials.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Lecia V. Sequist
Massachusetts General Hospital / Harvard Medical School
Mark G. Kris
Memorial Sloan Kettering Cancer Center
Geoffrey R. Oxnard
Foundation Medicine / Harvard Medical School
Alice T. Shaw
Novartis Institutes for BioMedical Research / Massachusetts General Hospital
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