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Translational Medicine / 转化医学Clinical Trials

Alice T. Shaw

M.D., Ph.D.

🏢Novartis Institutes for BioMedical Research🌐USA

Chief Medical Officer

2
Key Papers
2
Key Contributions

👥Biography 个人简介

Alice Shaw is a leader in the development of ALK inhibitors for lung cancer who led clinical trials establishing crizotinib, alectinib, and lorlatinib as standard treatments for ALK-positive NSCLC. Her work transformed ALK-positive lung cancer from rapidly fatal disease to one with meaningful long-term survival. Shaw now serves as CMO at Novartis.

Alice Shaw是肺癌ALK抑制剂开发的领导者,领导了确立crizotinib、alectinib和lorlatinib作为ALK阳性NSCLC标准治疗的临床试验。她的工作将ALK阳性肺癌从快速致死的疾病转变为具有有意义的长期生存的疾病。Shaw现在担任诺华的CMO。

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🧪Research Fields 研究领域

Lung Cancer肺癌
ALK InhibitorsALK抑制剂
Targeted Therapy靶向治疗

🎓Key Contributions 主要贡献

ALK Inhibitor Development

Led clinical development of multiple generations of ALK inhibitors.

Resistance Management

Characterized ALK resistance mechanisms and strategies to overcome them.

Representative Works 代表性著作

[1]

Crizotinib versus chemotherapy in advanced ALK-positive lung cancer

New England Journal of Medicine (2013)

Pivotal PROFILE 1007 trial.

[2]

Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer

New England Journal of Medicine (2017)

ALEX trial establishing alectinib as first-line standard.

📄Data Sources 数据来源

Last updated: 2026-03-05 | All information from publicly available academic sources

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