Alice T. Shaw
M.D., Ph.D.
Chief Medical Officer
👥Biography 个人简介
Alice Shaw is a leader in the development of ALK inhibitors for lung cancer who led clinical trials establishing crizotinib, alectinib, and lorlatinib as standard treatments for ALK-positive NSCLC. Her work transformed ALK-positive lung cancer from rapidly fatal disease to one with meaningful long-term survival. Shaw now serves as CMO at Novartis.
Alice Shaw是肺癌ALK抑制剂开发的领导者,领导了确立crizotinib、alectinib和lorlatinib作为ALK阳性NSCLC标准治疗的临床试验。她的工作将ALK阳性肺癌从快速致死的疾病转变为具有有意义的长期生存的疾病。Shaw现在担任诺华的CMO。
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ALK Inhibitor Development
Led clinical development of multiple generations of ALK inhibitors.
Resistance Management
Characterized ALK resistance mechanisms and strategies to overcome them.
Representative Works 代表性著作
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
New England Journal of Medicine (2013)
Pivotal PROFILE 1007 trial.
Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer
New England Journal of Medicine (2017)
ALEX trial establishing alectinib as first-line standard.
📄Data Sources 数据来源
Last updated: 2026-03-05 | All information from publicly available academic sources
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UCLA Jonsson Comprehensive Cancer Center
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Naiyer A. Rizvi
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