Drew M. Pardoll

Drew Pardoll is a pioneer in cancer immunology who has made foundational contributions to understanding the PD-1/PD-L1 pathway and its role in tumor immune evasion. His laboratory discovered that PD-L1 expression by tumor cells directly inhibits T cell function, providing the mechanistic basis for PD-1/PD-L1 blockade therapy. Pardoll continues to lead efforts to understand and overcome immunotherapy resistance.

Drew Pardoll是癌症免疫学的先驱，在理解PD-1/PD-L1通路及其在肿瘤免疫逃逸中的作用方面做出了基础性贡献。他的实验室发现肿瘤细胞表达的PD-L1直接抑制T细胞功能，为PD-1/PD-L1阻断治疗提供了机制基础。Pardoll继续领导理解和克服免疫治疗耐药的努力。