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Translational Medicine / 转化医学Clinical Trials

Antoni Ribas

M.D., Ph.D.

🏢UCLA Jonsson Comprehensive Cancer Center🌐USA

Director, Tumor Immunology Program

2
Key Papers
2
Key Contributions

👥Biography 个人简介

Antoni Ribas is a leading translational scientist bridging basic immunology with clinical cancer care. His research has been instrumental in understanding mechanisms of response and resistance to immune checkpoint inhibitors, particularly in melanoma. Ribas has led numerous practice-changing clinical trials and contributed to FDA approvals of multiple immunotherapy agents.

Antoni Ribas是连接基础免疫学与临床癌症护理的领先转化科学家。他的研究在理解免疫检查点抑制剂反应和耐药机制方面发挥了重要作用,特别是在黑色素瘤中。Ribas领导了众多改变实践的临床试验,并为多种免疫治疗药物的FDA批准做出了贡献。

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🧪Research Fields 研究领域

Melanoma Immunotherapy黑色素瘤免疫治疗
Checkpoint Inhibitors检查点抑制剂
Translational Oncology转化肿瘤学

🎓Key Contributions 主要贡献

Immunotherapy Resistance

Identified mechanisms of acquired resistance to PD-1 blockade including JAK mutations and beta-2-microglobulin loss.

Combination Strategies

Developed rational combination immunotherapy approaches based on resistance mechanisms.

Representative Works 代表性著作

[1]

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

New England Journal of Medicine (2016)

Identified JAK1/2 and B2M mutations as resistance mechanisms.

[2]

PD-1 Blockade Induces Responses by Inhibiting Adaptive Immune Resistance

Nature (2014)

Mechanistic insights into PD-1 blockade efficacy.

📄Data Sources 数据来源

Last updated: 2026-03-04 | All information from publicly available academic sources

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