Susan Kaech
苏珊·凯奇
PhD
Professor and Director, NOMIS Center for Immunobiology and Microbial PathogenesisNOMIS免疫生物学与微生物致病性中心主任教授
👥Biography 个人简介
Susan Kaech is a pioneer in T cell memory and exhaustion, elucidating transcriptional and metabolic programs that determine long-lived immunity versus dysfunction. Her work on epigenetic reprogramming of exhausted T cells is guiding development of more durable cancer immunotherapies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
T Cell Memory Formation
Defined transcriptional regulators controlling effector-to-memory T cell transition, establishing frameworks for vaccines and adoptive cell therapy design.
Epigenetics of T Cell Exhaustion
Revealed that exhaustion-associated chromatin remodeling constrains T cell reinvigoration by checkpoint blockade, guiding epigenetic reprogramming strategies.
Representative Works 代表性著作
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Nature Immunology (2003)
Identified IL-7R as a marker distinguishing memory precursor from terminal effector T cells, a foundational discovery for T cell memory biology.
The transcription factor TOX is a key regulator of T cell exhaustion
Nature (2019)
Established TOX as a master driver of the exhaustion epigenetic program, identifying a target for restoring anti-tumor T cell function.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Arlene Sharpe
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