Arlene H. Sharpe

Arlene Sharpe is a leading immunologist who has made fundamental contributions to understanding T cell costimulatory and coinhibitory pathways. Her work elucidated the function of PD-1 as an inhibitory receptor and demonstrated its role in peripheral tolerance and tumor immune evasion. Sharpe's research on the PD-1/PD-L1 pathway provided essential mechanistic insights for checkpoint inhibitor development.

Arlene Sharpe是领先的免疫学家，在理解T细胞共刺激和共抑制通路方面做出了基础性贡献。她的工作阐明了PD-1作为抑制性受体的功能，并证明了其在外周耐受和肿瘤免疫逃逸中的作用。Sharpe对PD-1/PD-L1通路的研究为检查点抑制剂的开发提供了重要的机制见解。