Alexander Rudensky
亚历山大·鲁坚斯基
PhD
Chair, Immunology Program; Howard Hughes Medical Institute Investigator免疫学项目主任；霍华德·休斯医学研究所研究员
👥Biography 个人简介
Alexander Rudensky is the world's foremost authority on regulatory T cells (Tregs) and Foxp3. His discoveries elucidating Treg development and suppressive function have transformed understanding of peripheral immune tolerance and how tumors exploit Tregs to evade immunity.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Foxp3 and Treg Biology
Established Foxp3 as the master regulator of Treg identity and function, defining the molecular basis of peripheral immune tolerance.
Tumor Immune Evasion by Tregs
Demonstrated mechanisms by which intratumoral Tregs suppress anti-tumor immunity, identifying targets to selectively deplete tumor Tregs.
Representative Works 代表性著作
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Nature Immunology (2003)
Proved Foxp3 is necessary and sufficient for Treg identity, a defining paper for the regulatory T cell field.
Regulatory T cell-derived interleukin-35 contributes to control of Th17 responses
Immunity (2011)
Revealed IL-35 as a key Treg effector cytokine with implications for cancer immune regulation.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Fred Hutchinson Cancer Center
Dan Littman
NYU Langone Health
Arlene Sharpe
Harvard Medical School
Gordon Freeman
Dana-Farber Cancer Institute
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