Dan Littman
丹·利特曼
MD, PhD
Kimberley and Eric J. Waldman Professor of Molecular Immunology分子免疫学金伯利与埃里克·沃尔德曼讲席教授
👥Biography 个人简介
Dan Littman has defined key transcriptional regulators of T helper cell differentiation, particularly Th17 and regulatory T cells. His work linking the gut microbiome to systemic T cell responses has reshaped understanding of immune homeostasis and cancer immunosurveillance.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Th17 Cell Differentiation
Identified RORγt as the master transcription factor governing Th17 cell development, providing a molecular handle for therapeutic modulation.
Gut Microbiome and Immunity
Demonstrated that specific gut commensal bacteria drive Th17 responses systemically, connecting microbiome composition to cancer therapy outcomes.
Representative Works 代表性著作
The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
Cell (2006)
Identified RORγt as the Th17 master regulator, a landmark discovery enabling targeted Th17 modulation in autoimmunity and cancer.
Induction of intestinal Th17 cells by segmented filamentous bacteria
Cell (2009)
Established causal link between a gut commensal bacterium and systemic Th17 responses, founding the microbiome-immunity interface field.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Philip Greenberg
Fred Hutchinson Cancer Center
Alexander Rudensky
Memorial Sloan Kettering Cancer Center
Arlene Sharpe
Harvard Medical School
Gordon Freeman
Dana-Farber Cancer Institute
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