Philip Greenberg
菲利普·格林伯格
MD
Head, Immunology Program免疫学项目主任
👥Biography 个人简介
Philip Greenberg is a pioneer in adoptive T cell therapy, developing strategies to engineer antigen-specific T cells for cancer treatment. His lab defined fundamental principles of T cell recognition and persistence in vivo, enabling modern TCR-based immunotherapies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Adoptive T Cell Therapy
Established foundational protocols for ex vivo expansion and adoptive transfer of tumor-specific T cells, informing clinical ACT trials worldwide.
TCR Engineering
Pioneered methods to redirect T cells via engineered TCRs targeting tumor antigens, broadening the scope of antigen-specific cancer immunotherapy.
Representative Works 代表性著作
Reconstitution of antigen-specific T cell immunity in immunodeficient hosts
Science (1988)
Seminal demonstration that antigen-specific CTLs could be adoptively transferred to restore protective immunity, founding the ACT field.
TCR-engineered T cells targeting WT1 in AML
Science Translational Medicine (2015)
Showed clinical benefit of TCR-redirected T cells against a leukemia-associated antigen, advancing solid tumor and hematologic ACT.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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留下邮箱，当我们发布与 Philip Greenberg（Fred Hutchinson Cancer Center）相关的新研究或访谈时，我们会通知你。
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