Sean Morrison
肖恩·莫里森
PhD
Director, Children's Research Institute; Mary McDermott Cook Chair in Pediatric Genetics儿童研究所所长；小儿遗传学玛丽·麦克德莫特·库克讲席教授
👥Biography 个人简介
Sean Morrison, PhD directs the Children's Research Institute at UT Southwestern and is a Howard Hughes Medical Institute Investigator. His lab demonstrated that melanoma does not follow a strict CSC hierarchy and that oxidative stress is a key vulnerability for metastasizing melanoma cells. He also showed that antioxidants promote melanoma metastasis, with major implications for cancer prevention.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Challenging the Strict CSC Hierarchy Model in Melanoma
Showed that in optimized xenograft conditions, virtually all melanoma cells can form tumors, challenging the notion of a rare CSC population and demonstrating high phenotypic plasticity in melanoma.
Oxidative Stress and Melanoma Metastasis
Demonstrated that metastasizing melanoma cells face lethal oxidative stress and must upregulate antioxidant defenses to survive, identifying ferroptosis vulnerability and showing that antioxidants paradoxically promote metastasis.
Neural Crest and Melanocyte Stem Cell Biology
Elucidated mechanisms regulating neural crest stem cell self-renewal and differentiation, providing a developmental framework for understanding melanoma cell-of-origin and tumor initiation.
Representative Works 代表性著作
Melanoma Originates from Cells with a Neural-Crest Gene Signature and Undergoes Phenotypic Switching
Nature (2008)
Demonstrated high frequency of tumor-initiating cells in melanoma under improved xenograft conditions, reshaping understanding of melanoma CSC hierarchy.
Antioxidants stimulate BACH1-dependent tumor angiogenesis
Nature (2019)
Revealed that antioxidants promote melanoma metastasis by reducing oxidative stress on circulating tumor cells, with implications for clinical use of antioxidant supplements.
Oxidative stress inhibits distant metastasis by human melanoma cells
Nature (2015)
Showed metastasizing melanoma cells must withstand elevated oxidative stress, identifying a metabolic vulnerability exploitable therapeutically.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Bing Ren
University of California San Diego, Ludwig Cancer Research
Cigall Kadoch
Dana-Farber Cancer Institute / Broad Institute of MIT and Harvard
Luciano Di Croce
Centre for Genomic Regulation (CRG), Barcelona
Alexander Meissner
Max Planck Institute for Molecular Genetics, Berlin
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