Bing Ren
任冰
PhD
Professor, Department of Cellular and Molecular Medicine; Ludwig Cancer Research Member细胞与分子医学系教授；路德维希癌症研究所成员
👥Biography 个人简介
Bing Ren is a leading authority on chromatin organization and gene regulation, credited with co-developing ChIP-on-chip and contributing pivotal methodology for mapping regulatory elements. His single-cell ATAC-seq and Hi-C studies have transformed understanding of cancer regulatory landscapes and 3D genome topology.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Single-Cell Chromatin Accessibility in Cancer
Pioneered single-cell ATAC-seq applications to dissect intratumor epigenetic heterogeneity, revealing rare cancer cell subpopulations with distinct regulatory programs driving resistance.
3D Genome Topology in Oncogenesis
Mapped topologically associating domains (TADs) and chromatin loops in cancer cells, demonstrating how structural variants disrupt insulator boundaries to activate oncogenes.
ENCODE Consortium Leadership
Led major contributions to the ENCODE project mapping regulatory elements genome-wide across human cell types, providing the foundational resource for interpreting cancer non-coding mutations.
Representative Works 代表性著作
A comparison of the functional and topological properties of enhancers and CTCF-binding sites in the human genome
Nature Genetics (2021)
Distinguished enhancer and insulator regulatory classes at single-cell resolution across human tissues and cancer types.
Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia
Nature Biotechnology (2020)
Applied simultaneous scRNA-seq and scATAC-seq to map gene regulatory networks driving lineage ambiguity in acute leukemia.
Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells
Genome Biology (2013)
Revealed 3D chromatin reorganization events linking topological changes to gene expression alterations in cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Bradley Bernstein
Massachusetts General Hospital / Broad Institute of MIT and Harvard
Cigall Kadoch
Dana-Farber Cancer Institute / Broad Institute of MIT and Harvard
Luciano Di Croce
Centre for Genomic Regulation (CRG), Barcelona
Stefan Pfister
German Cancer Research Center (DKFZ) / Hopp Children's Cancer Center (KiTZ), Heidelberg
关注 任冰 的研究动态
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留下邮箱，当我们发布与 Bing Ren（University of California San Diego, Ludwig Cancer Research）相关的新研究或访谈时，我们会通知你。
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