Bradley Bernstein
布拉德利·伯恩斯坦
MD, PhD
Professor of Pathology; Senior Associate Member, Broad Institute病理学教授；博德研究所高级副研究员
👥Biography 个人简介
Bradley Bernstein is a pioneer in cancer epigenomics, renowned for mapping histone modifications and enhancer landscapes in gliomas. His lab discovered how H3K27M mutations rewire the Polycomb epigenome in pediatric glioma and led major contributions to The Cancer Genome Atlas epigenomic profiling efforts.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
H3K27M Glioma Epigenomics
Elucidated how the H3K27M oncohistone mutation globally redistributes PRC2 activity, driving aberrant gene activation in diffuse intrinsic pontine glioma and providing new therapeutic targets.
Cancer Enhancer Reprogramming
Mapped genome-wide enhancer reprogramming events in glioblastoma stem cells, revealing how transcription factor networks and chromatin accessibility drive tumor plasticity and therapy resistance.
Cancer Epigenome Atlas
Led large-scale epigenomic profiling as part of TCGA and ENCODE consortia, generating reference chromatin state maps across dozens of cancer types that underpin the field.
Representative Works 代表性著作
H3K27M mutant gliomas reprogram the epigenome via PRC2 inhibition
Nature (2019)
Demonstrated that H3K27M oncohistones trap PRC2 at chromatin, leading to global H3K27me3 loss and focal gain at specific loci driving oncogenesis.
Epigenomic reprogramming during pancreatic cancer progression
Cell (2017)
Revealed that pancreatic cancer progression involves widespread enhancer remodeling that activates metastatic gene expression programs.
A chromatin landmark and transcription initiation at most promoters in human cells
Cell (2007)
Foundational study mapping H3K4me3 and H3K27me3 bivalent chromatin domains at developmental gene promoters in human ES cells.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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