Cigall Kadoch
西加尔·卡多奇
PhD
Associate Professor of Pediatric Oncology; Broad Institute Core Member儿科肿瘤学副教授；博德研究所核心成员
👥Biography 个人简介
Cigall Kadoch is the world's leading authority on the SWI/SNF (BAF) chromatin remodeling complex in cancer. She discovered the molecular mechanism of synovial sarcoma driven by SS18-SSX fusion and has systematically characterized how SWI/SNF subunit mutations drive ~20% of all human cancers, pioneering targeted epigenetic therapies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
SWI/SNF Complex Mechanism in Synovial Sarcoma
Discovered that the SS18-SSX oncofusion hijacks BAF complexes, evicting SMARCB1 and retargeting the complex to activate oncogenic gene programs, providing the first mechanistic model for synovial sarcoma.
SWI/SNF Mutations Across Cancer Types
Comprehensively catalogued SWI/SNF subunit mutations in ~20% of human cancers and established structure-function relationships explaining how specific subunit losses drive distinct malignancies.
Synthetic Lethality in SWI/SNF-Mutant Cancers
Identified PRC2 dependency as a synthetic lethal vulnerability in SMARCB1-deficient cancers, providing the mechanistic rationale for EZH2 inhibitor use in rhabdoid tumors and epithelioid sarcoma.
Representative Works 代表性著作
Proteomic and genomic approaches reveal critical functions of H3K27 methylation and BRD4 in pediatric rhabdoid tumor cells
Nature Genetics (2015)
Revealed PRC2-SWI/SNF antagonism as a key regulatory axis exploitable for therapy in SMARCB1-deficient tumors.
Functional and mechanistic landscape of the mammalian SWI/SNF complex in cancer
Nature Reviews Cancer (2022)
Comprehensive review detailing the biochemical diversity of BAF complexes and the spectrum of their oncogenic alterations.
SS18-SSX2 fusion oncoprotein mediates direct recruitment of the BAF complex to gene promoters
Cell (2013)
Determined that SS18-SSX drives BAF complex mistargeting, providing the molecular basis for synovial sarcoma tumorigenesis.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Bradley Bernstein
Massachusetts General Hospital / Broad Institute of MIT and Harvard
Bing Ren
University of California San Diego, Ludwig Cancer Research
Luciano Di Croce
Centre for Genomic Regulation (CRG), Barcelona
Stefan Pfister
German Cancer Research Center (DKFZ) / Hopp Children's Cancer Center (KiTZ), Heidelberg
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