Stefan Pfister
斯特凡·普菲斯特
MD
Division Head, Pediatric Neurooncology; Director, KiTZ儿科神经肿瘤学部门主任；KiTZ主任
👥Biography 个人简介
Stefan Pfister is the global leader in pediatric brain tumor epigenomics, renowned for developing the DNA methylation-based CNS tumor classifier used in diagnostic neuropathology worldwide. His work has defined the molecular subgroups of medulloblastoma, ependymoma, and DIPG, fundamentally transforming pediatric neuro-oncology.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DNA Methylation-Based CNS Tumor Classifier
Developed and validated the Heidelberg CNS tumor methylation classifier (www.molecularneuropathology.org), now integrated into WHO CNS tumor classification and used in diagnostic laboratories worldwide to resolve ambiguous diagnoses.
Molecular Subgroups of Medulloblastoma
Co-led landmark genomic studies defining four molecular subgroups of medulloblastoma (WNT, SHH, Group 3, Group 4) with distinct epigenomes, driver genes, and prognoses, reshaping stratified treatment approaches.
H3K27M DIPG Epigenomics
Performed comprehensive epigenomic profiling of H3K27M-mutant DIPG tumors, revealing global H3K27me3 redistribution patterns and identifying synthetic lethal dependencies informing clinical trials.
Representative Works 代表性著作
Molecular classification of brain tumors using DNA methylation profiling
Nature (2018)
Presented genome-wide methylation profiling of 2,801 CNS tumors across 82 methylation classes, establishing a reference for integrated CNS tumor diagnostics.
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Nature (2012)
Comprehensive genomic study revealing subgroup-specific structural variants and driver events in medulloblastoma, defining distinct biological entities.
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
Acta Neuropathologica (2012)
First large-scale clinicopathological characterization of H3K27M DIPG as a distinct and uniformly lethal entity.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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留下邮箱，当我们发布与 Stefan Pfister（German Cancer Research Center (DKFZ) / Hopp Children's Cancer Center (KiTZ), Heidelberg）相关的新研究或访谈时，我们会通知你。
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