Luciano Di Croce
卢西亚诺·迪·克罗切
PhD
ICREA Research Professor; Group Leader, Gene Regulation, Stem Cells and Cancer ProgrammeICREA研究教授；基因调控、干细胞与癌症研究项目组长
👥Biography 个人简介
Luciano Di Croce is a leading European expert on Polycomb-mediated gene silencing in cancer, particularly acute myeloid leukemia (AML). His research has defined how PRC1 and PRC2 complexes collaborate with oncofusion proteins to silence tumor suppressor programs, and how their dysregulation contributes to leukemic transformation.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Polycomb Complexes in AML Epigenetics
Demonstrated that AML oncofusion proteins such as PML-RARα and AML1-ETO recruit PRC complexes to aberrantly silence differentiation genes, establishing a mechanistic link between chromosomal translocations and epigenetic reprogramming.
Non-Canonical PRC1 Functions
Characterized the composition and genomic targeting of non-canonical PRC1 complexes in cancer cells, revealing distinct roles for PCGF paralogs in shaping H2AK119ub1 landscapes and gene repression.
Epigenetic Reprogramming in Stem Cell Plasticity
Identified how Polycomb-mediated bivalency is exploited during oncogenic reprogramming to maintain leukemia stem cell identity, providing new targets for differentiation therapy approaches.
Representative Works 代表性著作
PRC2-mediated epigenetic silencing impairs the anti-leukemic function of ATRA in acute promyelocytic leukemia
Nature Medicine (2020)
Showed that PRC2-driven silencing of retinoic acid target genes limits ATRA responsiveness in APL, with EZH2 inhibition restoring differentiation.
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and Polycomb domain formation
Cell (2014)
Established a hierarchical model of Polycomb domain assembly showing that variant PRC1 recruits PRC2 via H2AK119ub1.
Epigenetic regulation of stem cell fate by the oncofusion PML-RARα
Genes & Development (2013)
Defined how PML-RARα co-opts Polycomb machinery to block myeloid differentiation and drive the leukemia stem cell state.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Massachusetts General Hospital / Broad Institute of MIT and Harvard
Bing Ren
University of California San Diego, Ludwig Cancer Research
Cigall Kadoch
Dana-Farber Cancer Institute / Broad Institute of MIT and Harvard
Stefan Pfister
German Cancer Research Center (DKFZ) / Hopp Children's Cancer Center (KiTZ), Heidelberg
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留下邮箱，当我们发布与 Luciano Di Croce（Centre for Genomic Regulation (CRG), Barcelona）相关的新研究或访谈时，我们会通知你。
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