Alexander Meissner
亚历山大·迈斯纳
PhD
Director, Department of Genome Regulation基因组调控系主任
👥Biography 个人简介
Alexander Meissner is a world leader in DNA methylation biology, best known for pioneering reduced representation bisulfite sequencing (RRBS) and comprehensive methylome mapping in pluripotent and cancer cells. Formerly at Harvard, he now leads the Department of Genome Regulation at the Max Planck Institute for Molecular Genetics.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Reduced Representation Bisulfite Sequencing (RRBS)
Co-developed RRBS, enabling cost-effective genome-wide DNA methylation profiling at single-CpG resolution. This technology became a standard tool for methylome analysis in cancer and developmental biology.
DNA Methylation Dynamics During Reprogramming
Characterized genome-wide methylation reprogramming during iPSC generation and in cancer, revealing epigenetic barriers to reprogramming and aberrant methylation patterns acquired during oncogenic transformation.
Regulatory Element Methylation in Cancer
Demonstrated that differential methylation at enhancers and CpG island shores, rather than promoters alone, underlies gene expression changes in cancer, redefining how methylation influences the cancer epigenome.
Representative Works 代表性著作
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Nature (2008)
Produced comprehensive single-base resolution methylome maps of human ES cells and somatic cells, establishing a reference for epigenetic studies.
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
Nucleic Acids Research (2005)
Introduced RRBS as a scalable approach to profiling CpG-dense genomic regions at high depth.
The DNA methylation landscape of human cancer
Nature Reviews Cancer (2017)
Comprehensive review synthesizing mechanisms of global hypomethylation and focal hypermethylation in human cancers and their functional consequences.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Bradley Bernstein
Massachusetts General Hospital / Broad Institute of MIT and Harvard
Bing Ren
University of California San Diego, Ludwig Cancer Research
Cigall Kadoch
Dana-Farber Cancer Institute / Broad Institute of MIT and Harvard
Luciano Di Croce
Centre for Genomic Regulation (CRG), Barcelona
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