Natasha B. Leighl
娜塔莎·莱尔
MD, MMSc, FRCPC
Medical Oncologist; Professor of Medicine肿瘤内科医生；医学教授
👥Biography 个人简介
Dr. Natasha Leighl is a global lung cancer leader known for research on targeted therapy access, liquid biopsy, and NSCLC outcomes in diverse populations. She has led international clinical trials and advocates for equitable cancer care worldwide.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Global Access to Lung Cancer Therapy
Pioneered research on barriers to targeted therapy access in low- and middle-income countries, quantifying disparities and proposing policy solutions to improve NSCLC outcomes globally.
Liquid Biopsy Clinical Implementation
Led prospective studies demonstrating feasibility and clinical utility of plasma EGFR testing in routine NSCLC care, supporting guideline recommendations for non-invasive molecular testing.
International NSCLC Clinical Trials
Principal and co-investigator on numerous global EGFR and immunotherapy trials, contributing to evidence base for treatment of diverse NSCLC populations including Asian and elderly patients.
Representative Works 代表性著作
Plasma ctDNA as a Theranostic Platform in Non-Small Cell Lung Cancer
JAMA Oncology (2019)
Demonstrated prospective clinical utility of plasma EGFR testing in guiding first-line treatment decisions, supporting broader adoption of liquid biopsy.
Economic Analysis of Molecular Testing and Targeted Therapy in Advanced NSCLC
Journal of Clinical Oncology (2012)
Quantified cost-effectiveness of EGFR mutation testing, providing health economic justification for universal molecular profiling in lung cancer.
Erlotinib as Initial Treatment for Patients with Advanced EGFR-Mutation Positive NSCLC
Journal of Clinical Oncology (2010)
Contributed to Canadian perspective on first-line erlotinib efficacy, informing national treatment guidelines and access policy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Massachusetts General Hospital / Harvard Medical School
Mark G. Kris
Memorial Sloan Kettering Cancer Center
Geoffrey R. Oxnard
Foundation Medicine / Harvard Medical School
Alice T. Shaw
Novartis Institutes for BioMedical Research / Massachusetts General Hospital
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