Nada Jabado
纳达·贾巴多
MD, PhD, FRCP(C)
James McGill Professor of Pediatrics; Canada Research Chair in Pediatric Oncology麦吉尔大学詹姆斯·麦吉尔儿科教授；加拿大儿童肿瘤研究主席
👥Biography 个人简介
Nada Jabado is a pioneering physician-scientist at McGill University who co-discovered histone H3 K27M and G34 mutations as founding oncogenic events in pediatric gliomas, fundamentally reshaping understanding of pediatric brain tumor biology and inspiring an entirely new field of cancer epigenetics.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Discovery of H3K27M Mutation
Co-discovered the K27M mutation in histone H3.3 as the dominant oncogenic event in pediatric diffuse midline glioma, recognized as one of the most significant pediatric cancer biology findings of the decade.
H3G34 Glioma Biology
Characterized H3.3 G34R/V mutations in hemispheric pediatric high-grade glioma, revealing a distinct developmental cell-of-origin and chromatin dysregulation mechanism.
Epigenetic Therapeutic Targeting
Identified EZH2 and SETD2 pathway dependencies downstream of H3K27M, providing mechanistic rationale for epigenetic drug targeting in pediatric gliomas.
Representative Works 代表性著作
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
Nature Genetics (2012)
Co-discovery of H3.3 K27M and G34R/V mutations as hallmark alterations in pediatric high-grade gliomas.
SETD2 is a major tumor suppressor in pediatric glioma by restraining H3K36 dimethylation
Nature Genetics (2022)
Revealed SETD2 loss-of-function as a key epigenetic driver cooperating with H3G34 mutations in pediatric glioma.
Inhibition of EZH2 reverses H3K27me3 alterations and overcomes resistance in H3K27M gliomas
Science Translational Medicine (2020)
Demonstrated EZH2 inhibitor activity in H3K27M glioma models, providing preclinical basis for clinical trials.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Alexander Meissner
Max Planck Institute for Molecular Genetics, Berlin
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