Katerina Politi
卡特琳娜·波利蒂
PhD
Professor of Pathology and Medicine; Co-Director, Center for Thoracic Cancers病理学与医学教授；胸部肿瘤中心联合主任
👥Biography 个人简介
Dr. Katerina Politi is a leading cancer biologist who developed foundational mouse models of EGFR-mutant lung cancer and has systematically dissected mechanisms of osimertinib resistance. Her translational research accelerates the development of next-generation lung cancer therapies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Genetically Engineered Mouse Models of EGFR-Mutant Lung Cancer
Created highly predictive mouse models of EGFR-driven NSCLC that recapitulate human disease and drug responses, enabling mechanistic study of targeted therapy and resistance in vivo.
Osimertinib Resistance Mechanisms
Identified EGFR amplification, MET amplification, and epithelial-mesenchymal transition as key osimertinib resistance mechanisms, providing rationale for combination approaches to delay or overcome resistance.
Tumor Heterogeneity and Clonal Evolution
Characterized clonal dynamics and intra-tumor heterogeneity in EGFR-mutant NSCLC under therapeutic pressure, informing concepts of adaptive therapy and minimal residual disease monitoring.
Representative Works 代表性著作
Lung Adenocarcinomas Induced in Mice by Mutant EGF Receptors Previously Found in Human Lung Cancers
Cancer Cell (2006)
Foundational study establishing the first EGFR-mutant lung cancer mouse models, creating essential tools for the entire field of EGFR-targeted therapy research.
Mechanisms of Acquired Resistance to the EGFR Inhibitor Osimertinib
Cancer Discovery (2018)
Comprehensive genomic and functional dissection of osimertinib resistance, identifying actionable mechanisms including EGFR amplification and bypass signaling.
Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Vulnerabilities
Cancer Cell (2019)
Revealed that co-mutations with KRAS define functionally distinct NSCLC subtypes with different therapeutic dependencies, guiding combination therapy strategies.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Geoffrey R. Oxnard
Foundation Medicine / Harvard Medical School
Alice T. Shaw
Novartis Institutes for BioMedical Research / Massachusetts General Hospital
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