Guy A. Rouleau
盖伊·鲁洛
MD, PhD, FRSC
Director, Montreal Neurological Institute; Professor and Chair, Department of Neurology and Neurosurgery蒙特利尔神经病学研究所所长；神经病学和神经外科系主任
👥Biography 个人简介
Prof. Rouleau is a world-renowned neurogenetics pioneer who co-discovered the NF2 tumor suppressor gene and the schwannomatosis susceptibility genes SMARCB1 and LZTR1. His laboratory at the Montreal Neurological Institute has profoundly shaped understanding of genetic predisposition to brain and nerve tumors.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
NF2 Gene Discovery
Co-discovered and characterized the NF2 tumor suppressor gene encoding merlin, establishing its role in schwannoma, meningioma, and ependymoma, and laying the molecular foundation for all subsequent NF2 therapeutic research.
Schwannomatosis Genetics
Identified SMARCB1 and LZTR1 as schwannomatosis susceptibility genes, delineating the genetic landscape of this rare syndrome and providing diagnostic tools for families with multiple non-NF2 schwannomas.
Representative Works 代表性著作
Mutations in the Neurofibromatosis Type 2 Gene Are Found in Sporadic Meningiomas
Nature Genetics (1994)
Demonstrated that NF2 gene mutations occur in sporadic meningiomas, establishing merlin as a broad tumor suppressor relevant beyond NF2 syndrome and expanding therapeutic targeting implications.
LZTR1 Mutations Are Responsible for the Most Common Inherited Form of Schwannomatosis
Nature Genetics (2014)
Identified LZTR1 as a major schwannomatosis gene, resolving genetic etiology in a large proportion of familial schwannomatosis cases and establishing a new tumor suppressor pathway.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Alexander Meissner
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