D. Wade Clapp
韦德·克拉普
MD
Richard L. Schreiner Professor and Chair, Department of Pediatrics; Physician-in-Chief, Riley Hospital for Children儿科系主任；莱利儿童医院主任医师
👥Biography 个人简介
Dr. Clapp is a pioneering NF1 basic scientist whose laboratory established the critical role of mast cells and Ras signaling in NF1 tumor development. His genetically engineered mouse models have been foundational to NF1 research worldwide and underpinned multiple targeted therapy discoveries.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
NF1 Mast Cell Biology
Demonstrated that heterozygous mast cells are essential for plexiform neurofibroma formation in NF1, establishing a non-cell-autonomous tumor microenvironment paradigm with major therapeutic implications for NF1 treatment.
NF1 Animal Models
Developed conditional NF1 knockout mouse models that faithfully recapitulate human NF1 tumors, enabling mechanistic studies of Ras-driven oncogenesis and preclinical testing of targeted therapies including MEK inhibitors.
Representative Works 代表性著作
Heterozygosity at the Nf1 Locus Is Associated with Increased Mast Cell Recruitment
Nature Medicine (2001)
Landmark study demonstrating that NF1 haploinsufficient mast cells drive neurofibroma formation, establishing the tumor microenvironment as a critical driver of NF1 pathogenesis.
Targeted Inhibition of the MEK-ERK Pathway Reduces Tumor Growth in Nf1 Models
Cancer Cell (2013)
Preclinical validation of MEK inhibition in NF1 plexiform neurofibroma models, providing mechanistic rationale for selumetinib clinical trials and defining downstream Ras pathway targets.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Bing Ren
University of California San Diego, Ludwig Cancer Research
Cigall Kadoch
Dana-Farber Cancer Institute / Broad Institute of MIT and Harvard
Luciano Di Croce
Centre for Genomic Regulation (CRG), Barcelona
Alexander Meissner
Max Planck Institute for Molecular Genetics, Berlin
关注 韦德·克拉普 的研究动态
Follow D. Wade Clapp's research updates
留下邮箱，当我们发布与 D. Wade Clapp（Indiana University School of Medicine）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment