Chris Jones
克里斯·琼斯
PhD
Professor of Paediatric Brain Tumour Biology; Team Leader, Glioma Team儿童脑肿瘤生物学教授；胶质瘤研究团队负责人
👥Biography 个人简介
Chris Jones is a leading ICR researcher and world authority on DIPG and pediatric glioma epigenomics, who made foundational contributions to characterizing H3K27M biology, established the most comprehensive DIPG genomic dataset in Europe, and translates molecular insights into actionable clinical trial hypotheses.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DIPG Epigenomic Landscape
Generated comprehensive H3K27M DIPG epigenomic maps revealing global redistribution of H3K27me3 and H3K27ac, identifying super-enhancer-driven oncogenes as therapeutic targets.
DIPG Drug Resistance Mechanisms
Characterized molecular mechanisms of resistance to ONC201 and panobinostat in DIPG, including compensatory chromatin remodeling and kinase pathway rewiring driving treatment failure.
Multi-Omic DIPG Biobank
Established the UK's largest DIPG biobank with matched diagnostic, post-irradiation, and autopsy samples enabling longitudinal study of disease evolution and resistance development.
Representative Works 代表性著作
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
Nature Genetics (2014)
Co-discovered recurrent ACVR1 mutations as a second founding alteration in H3K27M DIPG, opening BMP pathway as a therapeutic target.
Comprehensive epigenomic analysis of H3K27M DIPG reveals super-enhancer reprogramming
Cancer Cell (2019)
Defined the global H3K27M-driven epigenomic landscape in DIPG, identifying super-enhancer-driven oncogenes amenable to BET bromodomain inhibition.
Acquired resistance mechanisms to ONC201 in H3K27M diffuse midline glioma
Nature Communications (2024)
Identified ClpP activator resistance mechanisms and combination strategies to overcome ONC201 resistance in DMG.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Bing Ren
University of California San Diego, Ludwig Cancer Research
Cigall Kadoch
Dana-Farber Cancer Institute / Broad Institute of MIT and Harvard
Luciano Di Croce
Centre for Genomic Regulation (CRG), Barcelona
Alexander Meissner
Max Planck Institute for Molecular Genetics, Berlin
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