Cédric Blanpain
塞德里克·布朗潘
MD, PhD
Professor and WELBIO Investigator, de Duve Institute德杜弗研究所教授兼WELBIO研究员
👥Biography 个人简介
Cédric Blanpain, MD PhD at ULB Brussels is a world leader in skin stem cell biology and cancer initiation. Using sophisticated genetic lineage tracing in mice, his lab identified the cells of origin of squamous cell carcinoma and basal cell carcinoma, dissected how normal stem cell programs are hijacked during tumor initiation, and defined the clonal dynamics of skin homeostasis and carcinogenesis.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Cell of Origin of Skin Cancers
Used inducible lineage tracing to demonstrate that squamous cell carcinoma and basal cell carcinoma arise from specific stem and progenitor populations in the interfollicular epidermis and hair follicle, defining the cells of origin for major skin cancers.
Clonal Dynamics of Skin Homeostasis and Cancer
Applied quantitative clonal analysis to dissect how single stem cells compete, expand, and generate preneoplastic fields in the skin, revealing early steps in tumor initiation before malignant transformation.
Cancer Stem Cells in Squamous Tumors
Identified and characterized CSC populations within squamous cell carcinomas, demonstrating their role in tumor maintenance, invasion, and resistance to therapy.
Representative Works 代表性著作
Clonal analysis of Notch1-regulated fate choices in the adult mouse skin
Nature Genetics (2010)
Showed that Notch1 loss in basal epidermal progenitors drives squamous cell carcinoma initiation from defined stem cell populations via clonal expansion.
Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors
Cell Stem Cell (2013)
Identified shared regulatory networks between normal skin stem cell self-renewal and cancer cell proliferation, revealing vulnerabilities in CSC maintenance.
The origin and evolution of cancer stem cells
Nature Reviews Cancer (2015)
Comprehensive review integrating lineage tracing data to describe how normal stem cells give rise to cancer stem cells across tissues.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Bing Ren
University of California San Diego, Ludwig Cancer Research
Cigall Kadoch
Dana-Farber Cancer Institute / Broad Institute of MIT and Harvard
Luciano Di Croce
Centre for Genomic Regulation (CRG), Barcelona
Alexander Meissner
Max Planck Institute for Molecular Genetics, Berlin
关注 塞德里克·布朗潘 的研究动态
Follow Cédric Blanpain's research updates
留下邮箱，当我们发布与 Cédric Blanpain（Université Libre de Bruxelles (ULB)）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment