Bharat Bhatt
巴拉特·巴特
PhD
Research Scientist, Institute for Stem Cell Biology and Regenerative Medicine干细胞生物学与再生医学研究所研究科学家
👥Biography 个人简介
Bharat Bhatt, PhD at Stanford University specializes in the regulation of cancer stem cells by their niche microenvironment. His research dissects how stromal cells, extracellular matrix, and cytokine signals in the tumor microenvironment maintain CSC identity, drive quiescence, and confer therapy resistance, with a focus on leukemia and solid tumor CSC niches.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Stromal Regulation of CSC Quiescence
Identified stromal cell-derived signals including CXCL12, SCF, and Angiopoietin-1 that anchor CSCs in quiescent niches, protecting them from chemotherapy-induced killing and enabling disease relapse.
Extracellular Matrix in CSC Maintenance
Demonstrated that fibronectin and laminin components of the CSC niche activate integrin signaling to sustain CSC self-renewal and prevent differentiation, highlighting ECM as a therapeutic target.
Niche Disruption as Anti-CSC Strategy
Developed experimental approaches to disrupt the CSC-niche interaction using CXCR4 antagonists and integrin-blocking antibodies, showing that niche mobilization sensitizes CSCs to conventional chemotherapy.
Representative Works 代表性著作
Niche regulation of cancer stem cells: implications for therapy resistance
Cell Stem Cell (2017)
Comprehensive analysis of how niche signals regulate CSC quiescence and therapy resistance, proposing combinatorial targeting of niche components with cytotoxic therapy.
Microenvironmental regulation of hematopoietic and leukemic stem cells
Trends in Cell Biology (2014)
Review of parallels between normal HSC niche regulation and leukemic stem cell niche exploitation, identifying therapeutic windows.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Bing Ren
University of California San Diego, Ludwig Cancer Research
Cigall Kadoch
Dana-Farber Cancer Institute / Broad Institute of MIT and Harvard
Luciano Di Croce
Centre for Genomic Regulation (CRG), Barcelona
Alexander Meissner
Max Planck Institute for Molecular Genetics, Berlin
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