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Translational Medicine / 转化医学MHC Restriction, Nobel Laureate 1996

Rolf Zinkernagel

MD, PhD

🏢University of Zurich🌐Switzerland

Emeritus Professor of Experimental Immunology

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👥Biography 个人简介

Rolf Zinkernagel shared the 1996 Nobel Prize in Physiology or Medicine with Peter Doherty for the discovery of MHC restriction of cytotoxic T cell recognition. Their work showed that T cells recognize antigen only in the context of self MHC molecules. This finding underpins modern concepts of antigen presentation and cellular immunity central to cancer immunotherapy.

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🧪Research Fields 研究领域

MHC restriction
CD8 T cells
viral immunity
Nobel Prize
adaptive immunity

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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