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Translational Medicine / 转化医学YTHDF Readers, mRNA Decay

Zhaoming Su

PhD

🏢Indiana University School of Medicine🌐USA

Associate Professor of Molecular and Cellular Biochemistry

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Key Contributions

👥Biography 个人简介

Zhaoming Su has elucidated the structural and functional mechanisms of YTHDF reader proteins that decode m6A modifications to regulate mRNA fate in cancer. His work on YTHDF2-mediated mRNA decay revealed how cancer cells selectively degrade tumor suppressor transcripts through m6A-dependent pathways. He has provided structural insights enabling rational design of small molecules targeting the m6A-reader interface.

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🧪Research Fields 研究领域

YTHDF2 mRNA decay
m6A reader proteins
YTH domain
post-transcriptional regulation
cancer mRNA stability

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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