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Translational Medicine / 转化医学Waldenstrom's Macroglobulinemia, CXCR4 Mutations

Zachary Hunter

PhD

🏢Dana-Farber Cancer Institute🌐USA

Research Director, Bing Center for WM

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👥Biography 个人简介

Zachary Hunter is the foremost expert on CXCR4 mutations in WM, having characterized the spectrum of CXCR4 somatic mutations (modeled after WHIM syndrome germline mutations) and their role in modifying BTK inhibitor response. Patients with CXCR4 mutations show attenuated ibrutinib responses, and Hunter's work has driven the development of CXCR4-directed therapies in WM. His genomic analyses have comprehensively profiled WM mutation landscapes.

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🧪Research Fields 研究领域

CXCR4 mutations WM
WHIM syndrome
ibrutinib resistance WM
WM genomics
mutation testing WM

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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