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Translational Medicine / 转化医学Glioma Clinical Research, IDH Targeted Therapy

W.K. Alfred Yung

MD

🏢MD Anderson Cancer Center🌐USA

Professor

62
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Key Papers
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Key Contributions

👥Biography 个人简介

Research on IDH-mutant lower-grade gliomas has advanced significantly with the INDIGO trial establishing vorasidenib (oral IDH1/2 inhibitor) for grade 2 IDH-mutant glioma — the first new treatment to improve progression-free survival in this disease in many years. IDH mutations occur in the majority of lower-grade gliomas and represent a key molecular target, with vorasidenib representing an important advance for this younger patient population.

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🧪Research Fields 研究领域

IDH1 IDH2 glioma treatment
vorasidenib IDH glioma INDIGO
low-grade glioma treatment
glioma bevacizumab clinical trials
brain tumor chemotherapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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