Yohann Loriot
约翰·洛里奥
MD, PhD
Associate Professor; Head of Urothelial Cancer Program副教授暨尿路上皮癌项目主任
👥Biography 个人简介
France's foremost bladder cancer translational researcher, Dr. Loriot pioneered FGFR2/3 inhibitor development in urothelial carcinoma including erdafitinib and pemigatinib trials, and co-leads ESMO and international consensus efforts defining molecular subtyping and targeted therapy pathways.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
FGFR2/3 Targeted Therapy
Led pivotal trials of FGFR inhibitors including erdafitinib (BLC2001) and pemigatinib in FGFR-altered urothelial carcinoma, demonstrating clinically meaningful response rates and contributing to the first FDA-approved targeted therapy for a molecularly defined bladder cancer subgroup.
Molecular Subtyping of Urothelial Cancer
Contributed to international consensus molecular classification of bladder cancer, defining luminal, basal, and neuronal subtypes with distinct therapeutic vulnerabilities that guide clinical trial design and targeted therapy selection.
Representative Works 代表性著作
Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma with FGFR Alterations (BLC2001)
New England Journal of Medicine (2019)
Phase II trial establishing erdafitinib activity in FGFR-altered urothelial carcinoma, supporting the first targeted therapy FDA approval in bladder cancer.
Pemigatinib in Patients with Relapsed or Refractory Urothelial Carcinoma with FGFR2/3 Alterations
Lancet Oncology (2022)
Phase II trial demonstrating pemigatinib activity in FGFR2/3-altered urothelial carcinoma, expanding the FGFR-targeted therapy landscape.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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