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Translational Medicine / 转化医学Phase I Dose-Finding Design, BOIN

Ying Yuan

PhD

🏢MD Anderson Cancer Center🌐USA

Professor

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Key Contributions

👥Biography 个人简介

Ying Yuan at MD Anderson developed BOIN (Bayesian Optimal Interval Design) — a widely adopted innovative Phase I dose-finding design for cancer trials that is simple to implement yet has optimal statistical properties for finding the maximum tolerated dose. BOIN and its derivatives (BOIN12, keyboard design) have been implemented in hundreds of cancer Phase I trials globally and represent a significant methodological advance in early-phase oncology trial design.

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🧪Research Fields 研究领域

BOIN dose-finding design cancer
phase I cancer trial design bayesian
optimal interval dose finding
continual reassessment method CRM
early phase oncology trial design

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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