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Translational Medicine / 转化医学Neuroblastoma, ALK Inhibitors

Yael Mosse

MD

🏢Children's Hospital of Philadelphia🌐USA

Professor of Pediatrics

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Key Contributions

👥Biography 个人简介

Yael Mosse at CHOP discovered ALK as the most common inherited predisposition gene for neuroblastoma and identified ALK as a therapeutic target in this disease. She led trials demonstrating crizotinib activity in ALK-mutated/amplified neuroblastoma and continues to develop ALK inhibitor strategies for this deadly childhood cancer. Her discovery opened a molecularly targeted treatment avenue for high-risk neuroblastoma.

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🧪Research Fields 研究领域

neuroblastoma
ALK mutations
crizotinib neuroblastoma
MYCN amplification
high-risk neuroblastoma

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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