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Translational Medicine / 转化医学HER2 NSCLC Translational

Xiuning Le

MD, PhD

🏢MD Anderson Cancer Center🌐USA

Associate Professor of Thoracic-Head and Neck Medical Oncology

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👥Biography 个人简介

Xiuning Le co-led DESTINY-Lung trials and translational studies of HER2-mutant NSCLC, investigating mechanisms of T-DXd response and resistance. Her work integrates tissue and ctDNA biomarkers to track HER2 alteration dynamics. She has defined HER2 amplification as a distinct therapeutic axis in NSCLC beyond activating mutations.

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🧪Research Fields 研究领域

DESTINY-Lung
T-DXd HER2 mutant NSCLC
HER2 amplification ctDNA
HER2 resistance mechanisms
HER2 transformation biology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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