Wolfgang Wick
沃尔夫冈·维克
MD
Director, Neurology Clinic and National Center for Tumor Diseases; DKFZ Division Head神经病学诊所暨国家肿瘤疾病中心主任；DKFZ部门负责人
👥Biography 个人简介
Director of Neurology at Heidelberg University Hospital and DKFZ division head, Wolfgang Wick leads the German Neuro-Oncology Working Group (NOA). His research on MGMT-stratified GBM treatment and lomustine-temozolomide combinations has refined first-line and elderly GBM management.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Lomustine-Temozolomide for MGMT-Methylated GBM
Led the CeTeG/NOA-09 trial showing lomustine plus temozolomide significantly improved OS in MGMT-methylated GBM over standard temozolomide alone, establishing a new first-line option.
Elderly GBM Treatment
Designed NOA-08 trial defining temozolomide monotherapy as a valid option for elderly MGMT-methylated GBM patients, sparing radiotherapy toxicity in this vulnerable population.
Representative Works 代表性著作
Lomustine and bevacizumab in progressive glioblastoma
New England Journal of Medicine (2017)
EORTC 26101 phase III trial showing no OS benefit of adding bevacizumab to lomustine in recurrent GBM.
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly
Lancet Oncology (2012)
NOA-08 trial establishing temozolomide monotherapy as an alternative to radiotherapy for elderly MGMT-methylated GBM.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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留下邮箱，当我们发布与 Wolfgang Wick（Heidelberg University Hospital / German Cancer Research Center (DKFZ)）相关的新研究或访谈时，我们会通知你。
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