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Translational Medicine / 转化医学Neuro-Oncology, GBM Temozolomide MGMT

Wolfgang Wick

MD

🏢Heidelberg University Hospital🌐Germany

Professor, Division of Neuro-Oncology

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Key Papers
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Key Contributions

👥Biography 个人简介

Wolfgang Wick has led landmark trials in GBM including the NOA-08 trial establishing temozolomide monotherapy for elderly MGMT-methylated GBM. His research has defined the predictive and prognostic roles of MGMT promoter methylation and explored alkylating agent strategies in subgroups of GBM patients. He is a leader in EORTC Brain Tumor Group trials and has shaped European standards for GBM treatment.

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🧪Research Fields 研究领域

MGMT promoter methylation GBM
temozolomide GBM
lomustine GBM
NOA-08 elderly GBM trial
GBM first-line therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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