William Tap
威廉·塔普
MD
Chief, Sarcoma Medical Oncology Service肉瘤内科肿瘤科主任
👥Biography 个人简介
William Tap, MD is Chief of Sarcoma Medical Oncology at MSK and a global leader in STS clinical trials. He led the ANNOUNCE phase III trial of olaratumab and has pioneered CDK4/MDM2-targeted therapy in well-differentiated and dedifferentiated liposarcoma. He chairs multiple national and international STS cooperative group studies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
STS Clinical Trials Leadership
Led or co-led pivotal STS trials including ANNOUNCE (olaratumab + doxorubicin) and multiple CDK4-inhibitor studies in liposarcoma, shaping global frontline therapy standards and understanding of trial design in rare tumors.
CDK4/MDM2-Targeted Therapy in Liposarcoma
Advanced the clinical development of palbociclib, abemaciclib, and MDM2 antagonists for WD/DD liposarcoma, correlating genomic amplification with clinical response in prospective studies.
Representative Works 代表性著作
Olaratumab and Doxorubicin versus Doxorubicin Alone for Treatment of Soft-Tissue Sarcoma (ANNOUNCE)
Lancet (2020)
Phase III ANNOUNCE trial that did not confirm OS benefit of olaratumab, providing critical lessons on STS trial design and biomarker enrichment.
Palbociclib in Patients with Well-Differentiated or Dedifferentiated Liposarcoma
Journal of Clinical Oncology (2022)
Demonstrated CDK4 inhibitor activity in CDK4-amplified liposarcoma, supporting a genomically-selected approach to this STS subtype.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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