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Translational Medicine / 转化医学Precision Medicine

William R. Sellers

M.D.

🏢Broad Institute🌐USA

Director, Cancer Program

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Key Papers
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Key Contributions

👥Biography 个人简介

William Sellers leads the Cancer Program at the Broad Institute, driving large-scale functional genomics efforts to identify cancer vulnerabilities. His research has characterized synthetic lethal interactions and developed CRISPR-based screening platforms for therapeutic target discovery. Previously, he led oncology research at Novartis.

William Sellers领导布罗德研究所的癌症项目,推动大规模功能基因组学工作以识别癌症脆弱性。他的研究描述了合成致死相互作用,并开发了用于治疗靶点发现的基于CRISPR的筛选平台。此前,他曾在诺华领导肿瘤学研究。

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🧪Research Fields 研究领域

Cancer Genomics癌症基因组学
Drug Discovery药物发现
Functional Genomics功能基因组学

🎓Key Contributions 主要贡献

Cancer Dependency Map

Leading DepMap project systematically identifying cancer vulnerabilities.

PTEN Biology

Characterized PTEN tumor suppressor function and therapeutic implications.

Representative Works 代表性著作

[1]

Defining a Cancer Dependency Map

Cell (2017)

Cancer Dependency Map methodology paper.

📄Data Sources 数据来源

Last updated: 2026-03-05 | All information from publicly available academic sources

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