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Translational Medicine / 转化医学Cancer Drug Resistance, Lung Cancer

William Pao

MD

🏢Roche / Genentech🌐USA

VP and CSO

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Key Papers
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Key Contributions

👥Biography 个人简介

William Pao has made fundamental contributions to understanding acquired resistance to EGFR inhibitors in lung cancer, characterizing the T790M resistance mutation and developing strategies to overcome it. His work bridging clinical observation to molecular mechanism has defined the drug resistance field in oncology. He subsequently moved to Roche/Genentech to translate these discoveries into new therapeutics.

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🧪Research Fields 研究领域

EGFR resistance
oncogene-driven lung cancer
drug resistance mechanisms
circulating tumor DNA
next-generation sequencing

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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