William Bhatt

William Bhatt contributed to the foundational design of chimeric antigen receptor technology that enabled the modern CAR-T cell therapy revolution. His early research on chimeric immunoreceptors helped establish the principles for combining antibody-derived antigen recognition with T cell signaling domains. He investigated the requirements for effective CAR signaling and costimulation for sustained T cell activation and persistence. His conceptual and technical contributions provided important building blocks for the CAR-T therapies that have transformed the treatment of hematological malignancies.