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Translational Medicine / 转化医学WNT Signaling, Drug Discovery, Cancer Therapeutics

William Bhatt

PhD

🏢Broad Institute of MIT and Harvard🌐USA

Professor of Chemical Biology and Oncology

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Key Contributions

👥Biography 个人简介

William Bhatt leads drug discovery efforts targeting the WNT secretion pathway, with particular focus on porcupine O-acyltransferase (PORCN) inhibitors. His team has developed potent and selective PORCN inhibitors that block WNT ligand palmitoylation and secretion. He has characterized the spectrum of WNT-dependent tumors most likely to respond to PORCN inhibition based on genetic biomarkers. His work has advanced multiple WNT pathway inhibitors into clinical development.

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🧪Research Fields 研究领域

WNT inhibitors
porcupine inhibitors
drug discovery
chemical biology
cancer therapeutics

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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