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Translational Medicine / 转化医学Ibrutinib Pharmacodynamics in CLL

Adrian Wiestner

MD, PhD

🏢National Heart, Lung, and Blood Institute (NIH)🌐USA

Senior Investigator, Hematology Branch

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Key Papers
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Key Contributions

👥Biography 个人简介

Adrian Wiestner led early translational studies of ibrutinib in CLL at the NIH that defined its pharmacodynamic effects on lymph node signaling. His serial sampling of patients in early trials clarified mechanisms of drug action and the kinetics of disease response. He continues to investigate targeted therapies in B cell malignancies.

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🧪Research Fields 研究领域

ibrutinib
CLL
BCR signaling
pharmacodynamics
translational hematology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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