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Translational Medicine / 转化医学Pseudouridine, RNA Modification Cancer

Wendy Gilbert

PhD

🏢Yale University🌐USA

Professor of Molecular Biophysics and Biochemistry

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Key Contributions

👥Biography 个人简介

Wendy Gilbert has advanced understanding of pseudouridine and other RNA modifications in cancer biology. Her transcriptome-wide pseudouridine mapping revealed dynamic regulation of this modification in cancer cells under stress conditions. She has demonstrated that cancer-specific changes in rRNA modifications create specialized ribosomes that preferentially translate oncogenic mRNAs, establishing ribosome heterogeneity as a cancer hallmark.

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🧪Research Fields 研究领域

pseudouridine cancer
rRNA modifications
snoRNA-guided modification
translation regulation
ribosome heterogeneity cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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