Ralph Weichselbaum

Ralph Weichselbaum has made seminal contributions to the molecular biology of radiation response and the abscopal effect, including the discovery that radiation activates the STING pathway through cytoplasmic DNA to stimulate type I interferon production and systemic anti-tumor immunity. His conceptualization of oligometastatic disease has provided a framework for using ablative radiation to trigger abscopal responses in patients with limited metastatic burden. He continues to elucidate mechanisms of radiation-induced immune signaling including exosome-mediated intercellular communication.