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Translational Medicine / 转化医学Colorectal Cancer Molecular

Wei Lian

连伟

MD, PhD

🏢Peking Union Medical College Hospital(北京协和医院)🌐China

Professor of Medical Oncology, Department of Internal Medicine Oncology肿瘤内科学教授

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Prof. Wei Lian at Peking Union Medical College Hospital is a leading authority on colorectal cancer immunotherapy in China, specializing in MSI-H/dMMR CRC treatment with immune checkpoint inhibitors and biomarker-driven patient selection in the Chinese population.

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🧪Research Fields 研究领域

Colorectal Cancer结直肠癌
MSI-H Immunotherapy微卫星高度不稳定免疫治疗
CRC Immunotherapy China中国结直肠癌免疫治疗
Molecular Biomarkers分子生物标志物

🎓Key Contributions 主要贡献

MSI-H CRC Immunotherapy in China

Led pivotal Chinese cohort studies characterizing MSI-H/dMMR prevalence and pembrolizumab efficacy in Chinese CRC patients, adapting global trial findings to Chinese population genomics and establishing national immunotherapy guidelines.

Molecular Biomarker Discovery in Chinese CRC

Identified population-specific molecular features of Chinese CRC patients including distinct mutational profiles, MSI prevalence patterns, and treatment response predictors, contributing to tailored treatment approaches for Asian CRC populations.

Representative Works 代表性著作

[1]

Prevalence and clinical significance of MSI-H/dMMR in Chinese colorectal cancer patients: a multicenter analysis

Chinese Journal of Cancer (2022)

Large multicenter Chinese study defining MSI-H/dMMR prevalence and immunotherapy response patterns in Chinese CRC.

[2]

Pembrolizumab in MSI-H/dMMR metastatic colorectal cancer: outcomes and biomarkers in Chinese patients

Cancer Medicine (2023)

Real-world efficacy and safety data for pembrolizumab in Chinese MSI-H metastatic CRC patients.

🏆Awards & Recognition 奖项与荣誉

🏆Chinese Society of Clinical Oncology (CSCO) Outstanding Young Investigator Award
🏆National Natural Science Foundation of China Research Grant
🏆Peking Union Medical College Hospital Clinical Excellence Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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