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Translational Medicine / 转化医学Anti-Angiogenic Therapy, DLL4/Notch

Warren Bhatt

PhD

🏢AstraZeneca Oncology🌐UK

Principal Scientist

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Key Papers
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Key Contributions

👥Biography 个人简介

Dr. Warren Bhatt is a vascular oncology drug developer who has investigated DLL4-Notch signaling in tumor angiogenesis. DLL4 expressed on endothelial tip cells activates Notch in neighboring cells to regulate tip-stalk cell patterning during vessel sprouting, and its inhibition dysregulates tumor vasculature. His work has contributed to the development of anti-DLL4 antibodies such as navicixizumab in combination with anti-VEGF therapy for gynecologic and other cancers.

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🧪Research Fields 研究领域

DLL4 delta-like ligand 4 angiogenesis
Notch signaling tumor vasculature
DLL4 Notch tumor stalk tip cell
anti-DLL4 navicixizumab cancer
DLL4 VEGF combination anti-angiogenic

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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