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Translational Medicine / 转化医学Myelodysplastic Syndromes, TP53 MDS

Virginia Klimek

MD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Associate Attending Physician, Leukemia Service

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Key Contributions

👥Biography 个人简介

Virginia Klimek is a clinical investigator specializing in TP53-mutated myelodysplastic syndromes and AML, a particularly challenging patient population with very poor outcomes using standard therapies. She has contributed to evaluation of APR-246 (eprenetapopt) in combination with azacitidine for TP53-mutated MDS in clinical trials. Her research characterizes the clonal dynamics of TP53-mutated hematopoietic cells and responses to novel therapeutic strategies. She is actively involved in developing rational combination approaches and supporting patients through clinical trials.

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🧪Research Fields 研究领域

TP53-mutated MDS
eprenetapopt APR-246
azacitidine TP53 MDS
complex karyotype MDS
MDS outcomes TP53

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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