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Translational Medicine / 转化医学Immune Checkpoints, TIM-3 and LAG-3

Vijay Kuchroo

DVSc, PhD

🏢Harvard Medical School / Brigham and Women's Hospital🌐USA

Samuel L. Wasserstrom Professor of Neurology

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Key Contributions

👥Biography 个人简介

Prof. Vijay Kuchroo is the discoverer of TIM-3 (T cell immunoglobulin and mucin domain-3) and a preeminent authority on co-inhibitory receptors in cancer and autoimmunity. His laboratory characterizes how TIM-3 and LAG-3 co-expression on exhausted tumor-infiltrating T cells creates a state of deep immunosuppression. His foundational work has driven clinical development of multiple TIM-3 and LAG-3 antibodies now in cancer immunotherapy trials.

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🧪Research Fields 研究领域

TIM-3 original discovery
LAG-3 co-inhibitory signaling
T cell exhaustion checkpoint regulation
multiple checkpoint co-expression
next-generation checkpoint immunotherapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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